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H3B-6527
Artikelnummer: TGM-T7738-100mg
Description: H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity. Target: FGFR. Smiles: CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1. References: Joshi, Jaya Julie, Coffey, Heather, Corcoran, Erik,et al. H3B-6527...
| Anwendung: | FGFR4 inhibitor |
| CAS | 1702259-66-2 |
| MW: | 629.54 D |
ab 63,00 €
H3B-6527
Artikelnummer: Cay26072-1
H3B-6527 is an inhibitor of FGF receptor 4 (FGFR4, IC50 = 50s = 320, 1,290, and 1,060 nM, respectively), as well as TAOK2, JNK2, and CSF1R (IC50s = 690, >10,000, and >10,000 nM, respectively). H3B-6527 increases the expression of the cytochrome P450 (CYP) isoform CYP7A1 and decreases phosphorylation of ERK1/2 in...
| Schlagworte: | N-[2-[[6-[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl]methylamino]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)ph... |
| Anwendung: | FGFR4 inhibitor |
| CAS | 1702259-66-2 |
| MW: | 629.5 D |
ab 111,00 €
