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Compound 401
Artikelnummer: Cay21769-1
Compound 401 is an inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR, IC50s = 0.28 and 5.3 µM, respectively). It is selective for DNA-PK and mTOR over PI3K, ATM, and ATR (IC50s = >100 µM for all). Compound 401 (10 µM) inhibits phosphorylation of the mTOR targets S6K1 and Akt...
| Schlagworte: | 2-(4-morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one |
| Anwendung: | DNA-PK / FRAP inhibitor |
| CAS | 168425-64-7 |
| MW: | 281.3 D |
ab 44,00 €
