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FzM1
Artikelnummer: Cay19074-5
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear...
| Schlagworte: | Frizzled M1, N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-urea |
| Anwendung: | Fz4 allosteric ligand |
| CAS | 1680196-54-6 |
| MW: | 360.4 D |
ab 56,00 €
FzM1
Artikelnummer: TGM-T24076-100mg
Description: FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=-6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the...
| Schlagworte: | FzM 1, FzM-1 |
| CAS | 1680196-54-6 |
| MW: | 360.43 D |
ab 34,00 €
