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PT2385
Artikelnummer: Cay21325-10
PT2385 is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha, IC50 = 12 nM). It inhibits HIF-2alpha-induced production of Vegfa mRNA and reduces tumor volume in a 786-O renal cell carcinoma mouse xenograft model when administered at a dose of 10 mg/kg. PT2385 (20 mg/kg) also inhibits the transcription of...
| Schlagworte: | 3-[[(1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro-benzonitrile |
| Anwendung: | HIF-2alpha inhibitor |
| CAS | 1672665-49-4 |
| MW: | 383.3 D |
ab 147,00 €
PT-2385
Artikelnummer: TGM-T7848-100mg
Description: PT-2385 is a selective inhibitor of HIF-2alpha with a dissociation constant (Kd) of less than 50 nM (Kd<50 nM). Target: HIF/HIF Prolyl-Hydroxylase, HIF. Smiles: CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)(F)[C@@H](O)c12. References: Eli Wallace, Ph.D. PT2385: HIF-2alpha Antagonist for the Treatment of...
| Anwendung: | HIF-2alpha inhibitor |
| CAS | 1672665-49-4 |
| MW: | 383.34 D |
ab 57,00 €
