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TAS 6417
Artikelnummer: Cay27911-10
TAS 6417 is a pan-EGFR inhibitor. It inhibits wild-type EGFR (IC50= 8 nM), as well as the EGFR point mutants EGFRL858R, EGFRL861Q, EGFRT790M, EGFRT790M/L858R (IC50s = 1.9, 5.5, 4.1, and 2 nM, respectively) and the insertion or deletion mutants EGFR D770_N771insNPG, EGFR d746-750, and EGFR d746-770/T790M (IC50s =...
| Schlagworte: | CLN-081, Zipalertinib, N-[(8S)-4-amino-8,9-dihydro-6-methyl-5-(3-quinolinyl)pyrimido[5,4-b]indolizin-8-yl]-2-propenamide |
| Anwendung: | Pan-EGFR inhibitor |
| CAS | 1661854-97-2 |
| MW: | 396.4 D |
ab 83,00 €
TAS6417
Artikelnummer: TGM-T16996-100mg
Description: TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM). Target: Apoptosis, EGFR. Smiles: CC1=C[C@@H](Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc21)NC(=O)C=C. References: Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion...
| Anwendung: | Pan-EGFR inhibitor |
| CAS | 1661854-97-2 |
| MW: | 396.44 D |
ab 84,00 €
