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GSK484 (hydrochloride)
Artikelnummer: Cay17488-5
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human...
| Schlagworte: | [(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]... |
| Anwendung: | Reversible PAD4 inhibitor |
| CAS | 1652591-81-5 |
| MW: | 510 D |
ab 52,00 €
GSK484 hydrochloride
Artikelnummer: TGM-TQ0067-100mg
Description: GSK484 hydrochloride (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. Target: PAD. Smiles: Cl.COc1cc(cc2nc(-c3cc4ccccc4n3CC3CC3)n(C)c12)C(=O)N1CC[C@@H](O)[C@@H](N)C1....
| Schlagworte: | AOB6992, GTPL8577 |
| Anwendung: | Reversible PAD4 inhibitor |
| CAS | 1652591-81-5 |
| MW: | 510.03 D |
ab 67,00 €
