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G-5555
Artikelnummer: TGM-T11342L-100mg
Description: G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively). Target: PAK. Smiles: CNc1ncc2cc(-c3ccc(cc3Cl)-c3cccc(C)n3)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1. References: Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving...
| CAS | 1648863-90-4 |
| MW: | 492.96 D |
ab 48,00 €
G-5555
Artikelnummer: Cay21469-5
G-5555 is an inhibitor of p21-activated kinase 1 (PAK1, Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50...
| Schlagworte: | 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimid... |
| Anwendung: | PAK1 Inhibitor |
| CAS | 1648863-90-4 |
| MW: | 493 D |
ab 61,00 €
