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IDH305
Artikelnummer: Cay24107-1
IDH305 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1, IC50s = 27, 28, and 6,140 nM for recombinant IDH1R132H, IDH1R132C, and wild-type IDH1, respectively). It reduces R-2-hydroxyglutarate (2-HG) production, a marker of mutant IDH1 activity, and inhibits growth of MCF-10A-IDH1R132H/+...
| Schlagworte: | (4R)-4-[(1S)-1-fluoroethyl]-3-[2-[[(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl]amino]-4-pyrimidinyl]-... |
| Anwendung: | IDH1 inhibitor |
| CAS | 1628805-46-8 |
| MW: | 490.5 D |
ab 133,00 €
IDH-305
Artikelnummer: TGM-T15550-10mg
Description: IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. It is 200-fold more selective for mutant IDH1 isoforms than wild type, with IC50s of 27 nM, 28 nM, and 6.14 nM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Target:...
| Anwendung: | IDH1 inhibitor |
| CAS | 1628805-46-8 |
| MW: | 490.45 D |
ab 49,00 €
