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Alofanib
Artikelnummer: Cay31754-5
Alofanib is an allosteric inhibitor of FGFR2. It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2alpha) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF, IC50 = 11...
| Schlagworte: | RPT835, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-benzoic acid |
| Anwendung: | Allosteric FGFR2 inhibitor |
| CAS | 1612888-66-0 |
| MW: | 413.4 D |
ab 128,00 €
Alofanib
Artikelnummer: TGM-T5122-100mg
Description: Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2...
| Schlagworte: | RPT835 |
| Anwendung: | Allosteric FGFR2 inhibitor |
| CAS | 1612888-66-0 |
| MW: | 413.4 D |
ab 30,00 €
