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Indirubin-3'-monoxime
Artikelnummer: Cay13314-5
Indirubin-3'-oxime is a potent inhibitor of glycogen synthase kinase 3beta (GSK3beta, IC50 = 22 nM). As GSK3beta phosphorylates tau protein, indirubin-3'-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer's disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher...
| Schlagworte: | 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one |
| Anwendung: | GSK-3beta inhibitor, CDK inhibitor |
| CAS | 160807-49-8 |
| MW: | 277.3 D |
ab 74,00 €
Indirubin-3'-monoxime
Artikelnummer: TGM-T5200-100mg
Description: Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3beta (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). Target: GSK-3, CDK, Lipoxygenase. Smiles: ON=C1C(Nc2ccccc12)=C1C(=O)Nc2ccccc12. References: Leclerc S, et al....
| Schlagworte: | Indirubin-3'-oxime |
| Anwendung: | GSK-3beta inhibitor, CDK inhibitor |
| CAS | 160807-49-8 |
| MW: | 277.28 D |
ab 31,00 €
