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ISRIB (trans-isomer)
Artikelnummer: TGM-T6183-100mg
Description: ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2alpha. Target: Apoptosis, Autophagy, PERK. Smiles: Clc1ccc(OCC(=O)N[C@H]2CC[C@@H](CC2)NC(=O)COc2ccc(Cl)cc2)cc1. References: Sidrauski C, et al. Elife....
| Schlagworte: | trans-ISRIB, trans-isomer, ISRIB, ISRIB trans-isomer |
| Anwendung: | EIF2AK3 / PERK inhibitor |
| CAS | 1597403-47-8 |
| MW: | 451.34 D |
ab 31,00 €
trans-ISRIB
Artikelnummer: Cay16258-5
Phosphorylation of eIF2alpha by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric...
| Schlagworte: | N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) |
| Anwendung: | EIF2AK3 / PERK inhibitor |
| CAS | 1597403-47-8 |
| MW: | 451.3 D |
ab 78,00 €
