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BAY1217389
Artikelnummer: TGM-T3434-10mg
Description: BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM). Target: Kinesin. Smiles: COc1ccc(Oc2cc(NCCC(F)(F)F)c3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)n3n2)c(F)c1F. References: Wengner AM, et al. Mol Cancer Ther. 2016, 15(4):583-92.
| Anwendung: | TTK inhibitor |
| CAS | 1554458-53-5 |
| MW: | 561.5 D |
ab 34,00 €
BAY 12-17389
Artikelnummer: Cay21660-1
BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1, IC50 = 0.63 nM). It is selective for Mps1 over a panel of kinases at 10 nM. BAY 12-17389 promotes cell-cycle progression into mitosis in metaphase-arrested HeLa cells (IC50 = 11 nM). BAY 12-17389 (1.5 mg/kg) enhances paclitaxel-induced inhibition of tumor...
| Schlagworte: | N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-... |
| Anwendung: | TTK inhibitor |
| CAS | 1554458-53-5 |
| MW: | 561.5 D |
ab 52,00 €
