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BMS-P5
Artikelnummer: Cay33581-10
BMS-P5 is an inhibitor of protein arginine deiminase 4 (PAD4, IC50 = 0.098 µM). It is selective for PAD4 over PAD1, -2, and -3 (IC50s = >10 µM for all). BMS-P5 (1 µM) inhibits citrullination of histone H3 and neutrophil extracellular trap (NET) formation induced by RPMI-8226- or MM.1S-conditioned medium in isolated...
| Schlagworte: | [(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-met... |
| Anwendung: | PADI4 inhibitor |
| CAS | 1550371-22-6 |
| MW: | 472.6 D |
ab 51,00 €
BMS-P5 free base
Artikelnummer: TGM-T22277L-100mg
Description: BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor that blocks the formation of Neutrophil Extracellular Traps and delays the progression of multiple myeloma. Administration of BMS-P5 to multiple myeloma-bearing mice delays symptom onset and disease...
| Anwendung: | PADI4 inhibitor |
| CAS | 1550371-22-6 |
| MW: | 472.58 D |
ab 77,00 €
