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COH000
Artikelnummer: Cay34906-5
COH000 is an inhibitor of SUMO-activating enzyme (SAE, IC50 = 0.2 µM), a heterodimer composed of SAE1 and SAE2. It is selective for SAE over ubiquitin-activating enzyme (UAE) and NEDD8-activating enzyme (NAE) at 10 µM. COH000 induces degradation of SAE2 in HCT116 human colon cancer cells. COH000 (10 mg/kg) induces...
| Schlagworte: | (1R,4S)-1-[(1R)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid,... |
| Anwendung: | SUMO-activating enzyme inhibitor |
| CAS | 1534358-79-6 |
| MW: | 419.5 D |
ab 99,00 €
COH000
Artikelnummer: TGM-T5199-100mg
Description: COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 µM in vitro). Target: E1/E2/E3 Enzyme. Smiles: [H][C@]12O[C@@](C=C1)([C@@H](Cc1ccc(C)cc1)Nc1ccccc1)C(C(=O)OC)=C2C(=O)OC. References: Li YJ, et al. Allosteric...
| Anwendung: | SUMO-activating enzyme inhibitor |
| CAS | 1534358-79-6 |
| MW: | 419.47 D |
ab 187,00 €
