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Taletrectinib
Artikelnummer: Cay45040-1
An ROS1, TrkA, and TrkC inhibitor (IC50s = 0.207, 0.622, and 0.98 nM, respectively), selective for these kinases over TrkB (IC50 = 2.28 nM), reduces the viability of JFCR-165, JFCR-168, and MGH193-1B patient-derived ROS1-CD74 fusion protein-positive NSCLC cells from 1-10,000 nM, reduces tumor volume in Ba/F3 mouse...
| Schlagworte: | AB-106, DS-6051b, 3-[4-[(2R)-2-aminopropoxy] phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-Imidazo[1,2-b]pyridazin-6-amine |
| Anwendung: | ROS1 / TrkA / TrkC inhibitor |
| CAS | 1505514-27-1 |
| MW: | 405.48 D |
ab 137,00 €
Taletrectinib free base
Artikelnummer: TGM-T38995-100mg
Description: Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also...
| Schlagworte: | Taletrectinib free base, AB-106freebase, IBI-344 free base, DS-6051b free base |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1] (ROS1) |
| CAS | 1505514-27-1 |
| MW: | 405.47 D |
ab 61,00 €
