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GNE-3511
Artikelnummer: Cay19174-10
GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK), also known as MAP3K12 (Ki = 500 pM). It also inhibits phosphorylated JNK (IC50 = 30 nM) and is highly selective for DLK over other MAP kinases (IC50 > 5,000 nM for MKK4 and MKK7), JNKs (IC50s = 129, 514, and 364 nM for JNK1,...
| Schlagworte: | 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-4-pyridinecarbonitrile |
| CAS | 1496581-76-0 |
| MW: | 440.5 D |
ab 68,00 €
NEU
GNE-3511
Artikelnummer: TGM-T3707-10mg
Description: GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors. Target: MAPK, DNA Alkylation. Smiles: FC1(F)CCN(C1)c1cc(cc(Nc2cc(ccn2)C#N)n1)C1CCN(CC1)C1COC1. References: Patel S, et al. J Med Chem. 2015 Jan 8,58(1):401-18.
| Schlagworte: | GNE3511 |
| CAS | 1496581-76-0 |
| MW: | 440.49 D |
ab 41,00 €
