Zu "1472795-20-2" wurden 2 Artikel gefunden!
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KRCA 0008
Artikelnummer: Cay43933-10
KRCA 0008 is an inhibitor of anaplastic lymphoma kinase (ALK) and tyrosine non-receptor kinase 2 (TNK2), also known as activated Cdc42 kinase 1 (ACK1, IC50s = 12 and 4 nM, respectively). It is selective for these kinases over the insulin receptor (InsR, IC50 = 210 nM). KRCA 0008 also inhibits the ALK mutants...
| Schlagworte: | 1-phenylene)-4,1-piperazinediyl]]bis-1,1'-[(5-chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4 ethanone |
| Anwendung: | ALK / TNK2 inhibitor |
| CAS | 1472795-20-2 |
| MW: | 609,13 D |
ab 45,00 €
KRCA-0008
Artikelnummer: TGM-T2641-100mg
Description: KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM), displays drug-like properties without hERG liability. Target: ACK, ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccc(cc2OC)N2CCN(CC2)C(C)=O)n1)N1CCN(CC1)C(C)=O. References: Park CH, et al. Bioorg Med Chem Lett. 2013 Nov 15,23(22):6192-6.
| Schlagworte: | KRCA 0008, KRCA0008 |
| CAS | 1472795-20-2 |
| MW: | 609.12 D |
ab 38,00 €
