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PF-06424439 methanesulfonate
Artikelnummer: TGM-T12425-100mg
Description: PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate,...
| Anwendung: | DGAT2 inhibitor |
| CAS | 1469284-79-4 |
| MW: | 536.05 D |
ab 40,00 €
PF-06424439
Artikelnummer: Cay17680-1
PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2, IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 µM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent...
| Schlagworte: | [(3R)-1-[2-[1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanon... |
| Anwendung: | DGAT2 inhibitor |
| CAS | 1469284-79-4 |
| MW: | 536 D |
ab 61,00 €
