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Adavivint
Artikelnummer: Cay43927-1
Adavivint is an inhibitor of Wnt signaling (EC50 = 19. nM in a reporter assay using SW480 cells). It inhibits CMGC family kinases, including CDC-like kinase 2 (Clk2) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A, IC50s = 7. and 26. nM, respectively), as well as Clk1, Clk3, Clk4, DYRK1B,...
| Schlagworte: | Lorecivivint, SM-04690,... |
| Anwendung: | Wnt signaling inhibitor |
| CAS | 1467093-03-3 |
| MW: | 505.56 D |
ab 38,00 €
Adavivint
Artikelnummer: TGM-T5636-100mg
Description: Adavivint (SM04690) is a selective inhibitor of the typical Wnt signaling pathway. In SW480 cells, EC50=19.5 nM was measured using high-throughput TCF/LEF reporter gene experiments. Target: Wnt/beta-catenin. Smiles: CC(C)CC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1. References:...
| Schlagworte: | Adavivint (SM04690) |
| Anwendung: | Targets dual specificity protein kinase CLK2/3 [EC:2.7.12.1] (CLK2_3) |
| CAS | 1467093-03-3 |
| MW: | 505.55 D |
ab 39,00 €
