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LY3009120
Artikelnummer: Cay21504-5
LY3009120 is an inhibitor of Raf kinases, including A-Raf, B-Raf, and c-Raf (IC50s = 44, 31-47, and 42 nM, respectively, in whole cell lysates). It also inhibits B-Raf mutants V600E and V600E+G468A (IC50s = 5.8 and 17 nM, respectively, in biochemical assays). LY3009120 induces Raf dimerization and, unlike...
| Schlagworte: | DP-4978, N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-urea |
| Anwendung: | Raf inhibitor |
| CAS | 1454682-72-4 |
| MW: | 424.5 D |
ab 211,00 €
LY3009120
Artikelnummer: TGM-T6882-100mg
Description: LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 values of 44 nM for A-raf, 31-47 nM for B-Raf, and 42 nM for C-Raf in A375 cells. Phase 1. Target: Raf, Autophagy. Smiles: CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C. References: Henry JR, et al. J Med Chem. 2015, 58(10), 4165-4179.
| Schlagworte: | DP-4978 |
| Anwendung: | Raf inhibitor |
| CAS | 1454682-72-4 |
| MW: | 424.51 D |
ab 30,00 €
