Zu "1449277-10-4" wurden 2 Artikel gefunden!
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GNE-495
Artikelnummer: Cay21808-1
GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name:...
| Schlagworte: | 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide |
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.4 D |
ab 67,00 €
GNE-495
Artikelnummer: TGM-TQ0079-1mg
Description: GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. Target: MAPK. Smiles: Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1. References: Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS...
| Anwendung: | MAP4K4 inhibitor |
| CAS | 1449277-10-4 |
| MW: | 405.42 D |
ab 34,00 €
