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voxelotor
Artikelnummer: TGM-T7581-100mg
Description: Voxelotor (GBT 440) is an inhibitor of sickle hemoglobin (HbS). Target: Others. Smiles: CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O. References: Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease[J]. Hematology Reports, 2018, 10(2).
| Schlagworte: | GBT 440 |
| Anwendung: | Antianemic, Hemoglobin S polymerization inhibitor |
| CAS | 1446321-46-5 |
| MW: | 337.37 D |
ab 34,00 €
GBT-440
Artikelnummer: Cay23933-5
GBT-440 is a modulator of sickle hemoglobin (HbS) that binds covalently to the N-terminal valine of the alpha chain of HbS. In vitro, GBT-440 increases HbS affinity for oxygen (EC50s = 8.2 and 415 µM for purified HbS and whole blood from sickle cell anemia patients, respectively) and delays oxygen release from and...
| Schlagworte: | Voxelotor, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde |
| Anwendung: | HbS modulator |
| CAS | 1446321-46-5 |
| MW: | 337.4 D |
ab 34,00 €
