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ME0328
Artikelnummer: Cay18488-5
The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression. It...
| Schlagworte: | 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide |
| Anwendung: | PARP3 inhibitor |
| CAS | 1445251-22-8 |
| MW: | 321.4 D |
ab 59,00 €
ME0328
Artikelnummer: TGM-T6578-100mg
Description: ME0328 is a potent, selective PARP inhibitor with an IC50 of 0.89 µM for PARP3, showing approximately 7-fold selectivity over PARP1. Target: PARP. Smiles: C[C@H](NC(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccccc1. References: Lindgren AE, et al. ACS Chem Biol. 2013, 8(8), 1698-1703.
| Anwendung: | PARP3 inhibitor |
| CAS | 1445251-22-8 |
| MW: | 321.37 D |
ab 40,00 €
