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3-AP
Artikelnummer: Cay15419-1
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 µM...
| Schlagworte: | 3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone, NSC 663249, Triapine(TM),... |
| Anwendung: | Ribonucleotide reductase inhibitor |
| CAS | 143621-35-6 |
| MW: | 195.2 D |
ab 51,00 €
3-AP
Artikelnummer: TGM-T1982-100mg
Description: 3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR). Target: DNA/RNA Synthesis. Smiles: NC(=S)N\N=C\c1ncccc1N. References: Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J...
| Schlagworte: | OCX191, PAN-811, NSC663249, Triapine |
| Anwendung: | Ribonucleotide reductase inhibitor |
| CAS | 143621-35-6 |
| MW: | 195.24 D |
ab 32,00 €
