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A 419259 trihydrochloride
Artikelnummer: TGM-TQ0132-100mg
Description: A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn). Target: Src. Smiles: Cl.Cl.Cl.CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12. References: Wilson MB, et al. Selective pyrrolo-pyrimidine...
| Schlagworte: | RK 20449 trihydrochloride |
| Anwendung: | Src family kinase inhibitor |
| CAS | 1435934-25-0 |
| MW: | 592 D |
ab 48,00 €
A-419259 (hydrochloride)
Artikelnummer: Cay18168-1
A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, 50 = 3,000 nM) and PKC (IC50 = >33 µM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 µM, respectively), but not Ph- TF-1 and HEL cells....
| Schlagworte: | RK-20449, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine,... |
| Anwendung: | Src family kinase inhibitor |
| CAS | 1435934-25-0 |
| MW: | 592 D |
ab 61,00 €
