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ML-216
Artikelnummer: Cay15186-1
. Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first...
| Schlagworte: | CID-49852229, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea |
| Anwendung: | BLM helicase inhibitor |
| CAS | 1430213-30-1 |
| MW: | 383.3 D |
ab 51,00 €
ML216
Artikelnummer: TGM-T5413-100mg
Description: ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase with an IC50 of 1.8 µM, demonstrating 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 µM). Target: DNA/RNA Synthesis. Smiles: Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F. References:...
| Schlagworte: | CID-49852229 |
| Anwendung: | BLM helicase inhibitor |
| CAS | 1430213-30-1 |
| MW: | 383.32 D |
ab 54,00 €
