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UNC2025
Artikelnummer: Cay16613-5
UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...
| Schlagworte: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Anwendung: | Mer/FLT3 dual inhibitor |
| CAS | 1429881-91-3 |
| MW: | 476.7 D |
ab 112,00 €
UNC2025
Artikelnummer: TGM-T7007-100mg
Description: UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3. Target: TAM Receptor, FLT. Smiles: CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1. References: Zhang W, et al. J...
| Schlagworte: | mrx-6313, UNC 2025, UNC-2025 |
| Anwendung: | Mer/FLT3 dual inhibitor |
| CAS | 1429881-91-3 |
| MW: | 476.66 D |
ab 32,00 €
