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CDKI-73
Artikelnummer: TGM-T14919-100mg
Description: CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. Target: Apoptosis, CDK. Smiles:...
| Anwendung: | Cdk9-cyclin T1 / Cdk1-cyclin B / Cdk2-cyclin A inhibitor |
| CAS | 1421693-22-2 |
| MW: | 394.45 D |
ab 145,00 €
CDKI-73
Artikelnummer: Cay41099-10
CDKI-73 is an inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively). It is selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM). CDKI-73 is cytotoxic to HCT116 colorectal cancer cells (GI50 = In vivo, CDKI-73 (100 mg/kg every three days)...
| Schlagworte: | Asnuciclib, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide |
| Anwendung: | Cdk9-cyclin T1 / Cdk1-cyclin B / Cdk2-cyclin A inhibitor |
| CAS | 1421693-22-2 |
| MW: | 394.4 D |
ab 94,00 €
