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Crenigacestat
Artikelnummer: TGM-T3633-10mg
Description: Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor...
| Schlagworte: | LY3039478 |
| Anwendung: | Targets Notch 1 (NOTCH1) |
| CAS | 1421438-81-4 |
| MW: | 464.44 D |
ab 57,00 €
Crenigacestat
Artikelnummer: Cay27919-1
Crenigacestat is an orally bioavailable Notch inhibitor. It induces cell cycle arrest at the G0/G1 phase and decreases expression of the oncogenes MYC and CCNA1 in Caki human renal cancer cells. Crenigacestat (8 mg/kg per day) reduces tumor growth and increases survival in a 769-P mouse xenograft model.Formal Name:...
| Schlagworte: | LY3039478,... |
| Anwendung: | Notch inhibitor, antineoplastic |
| CAS | 1421438-81-4 |
| MW: | 464.4 D |
ab 61,00 €
