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LAS191859
Artikelnummer: Cay20238-1
LAS191859 is a potent antagonist of CRTH2/DP2 with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively. It is selective for CRTH2/DP2 over a panel of 65 enzymes, ion channels, and transporters with 50s = 2 and 8.2 nM in isolated eosinophils...
| Schlagworte: | 1-[2-[[(cyclopropylcarbonyl)ethylamino]methyl]-4-(trifluoromethyl)phenyl]-6-methyl-1H-pyrrolo[2,3-b]pyridine-3-acetic acid |
| Anwendung: | Prostaglandin D2 receptor 2 antagonist |
| CAS | 1420071-13-1 |
| MW: | 459.5 D |
ab 235,00 €
LAS191859
Artikelnummer: TGM-T27799-1mg
Description: LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasting in vivo efficacy that is independent of plasma...
| Schlagworte: | LAS-191859, LAS 191859 |
| Anwendung: | Prostaglandin D2 receptor 2 antagonist |
| CAS | 1420071-13-1 |
| MW: | 459.46 D |
ab 540,00 €
