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PF-06465469
Artikelnummer: Cay31118-10
PF-06465469 is a covalent inhibitor of IL-2-inducible T cell kinase (Itk, IC50 = 2 nM). It also inhibits Bruton's tyrosine kinase (BTK, IC50 = 2 nM). PF-06465469 inhibits Itk phosphorylation of phospholipase Cgamma (PLCgamma) induced by an anti-CD3 antibody in Jurkat cells (IC50 = 57 nM). It induces apoptosis in...
| Schlagworte: | 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)... |
| Anwendung: | Itk covalent inhibitor |
| CAS | 1407966-77-1 |
| MW: | 523.63 D |
ab 147,00 €
PF-06465469
Artikelnummer: TGM-T16493-100mg
Description: PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM). Target: Others. Smiles: CC(C)c1ccc(NC(=O)c2cccc(c2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C. References: Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma....
| CAS | 1407966-77-1 |
| MW: | 523.63 D |
ab 678,00 €
