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Navoximod
Artikelnummer: TGM-TQ0071-100mg
Description: Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM). Target: Indoleamine 2,3-Dioxygenase (IDO). Smiles: [H][C@@]1(CC[C@H](O)CC1)[C@H](O)C[C@H]1c2c(cccc2F)-c2cncn12. References: Mario R. Mautino, et al. Abstract 491: NLG919, a...
| Schlagworte: | GDC-0919, NLG-919 |
| Anwendung: | Targets indoleamine 2,3-dioxygenase [EC:1.13.11.52] (IDO, INDO) |
| CAS | 1402837-78-8 |
| MW: | 316.37 D |
ab 152,00 €
Navoximod
Artikelnummer: Cay28440-1
An IDO1 inhibitor (IC50 = 28 nM for the recombinant human enzyme), decreases tumor volume in a Panc02 murine PDAC model at 500 mg/kg. Formulation: A solid. InChI: InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11-,12-,15-,17+/m0/s1....
| Schlagworte: | GDC-0919, NLG-919, RG6078, (aR,5S)-6-fluoro-a-(trans-4-hydroxycyclohexyl)-5H-imidazo[5,1-a]isoindole-5-ethanol |
| Anwendung: | IDO1 inhibitor |
| CAS | 1402837-78-8 |
| MW: | 316.4 D |
ab 239,00 €
