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Pyrotinib dimaleate
Artikelnummer: TGM-T12594-100mg
Description: Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent, selective dual inhibitor of EGFR and HER2, with IC50 values of 13 nM and 38 nM, respectively. Target: HER, EGFR. Smiles: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\[C@H]1CCCN1C. References: Li X,...
| Schlagworte: | SHR-1258 dimaleate |
| CAS | 1397922-61-0 |
| MW: | 815.22 D |
ab 148,00 €
Pyrotinib (maleate)
Artikelnummer: Cay42108-1
An EGFR and HER2 inhibitor (IC50s = 13 and 38 nM, respectively), selectively inhibits the proliferation of HER2+ BT474 and SKOV3 cells (IC50s = 5.1 and 43 nM, respectively) over HER2- MDA-MB-231 cells (IC50 = 3,500 nM), decreases tumor growth without affecting body weight in BT474 and SKOV3 mouse xenograft models at...
| Schlagworte: | SHR-1258,... |
| Anwendung: | EGFR / HER2 inhibitor |
| CAS | 1397922-61-0 |
| MW: | 815.2 D |
ab 214,00 €
