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GNE-2861
Artikelnummer: Cay29458-5
GNE-2861 is an inhibitor of the group 2 p21-activated kinases (PAKs, IC50s = 7.5, 126, and 36 nM for PAK4, -5, and -6, respectively). It is selective for group 2 PAKs over group 1 PAKs (IC50s = 5.42, 0.97, and >10 µM for PAK1, -2, and -3, respectively), as well as JAK3, KHS1, MAP4K4, and MINK1 at 1 µM. GNE-2861...
| Schlagworte: | 1-[2-[1-(2-amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]-cyclohexanol |
| Anwendung: | Group 2 p21-activated kinase (PAK4, PAK5, PAK6) inhibitor |
| CAS | 1394121-05-1 |
| MW: | 406.5 D |
450,00 €
GNE 2861
Artikelnummer: TGM-T16429-100mg
Description: GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity. Target: PAK. Smiles: COCCNc1nc2ccc(cc2n1-c1ccnc(N)n1)C#CC1(O)CCCCC1. References: Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective...
| Anwendung: | Group 2 p21-activated kinase (PAK4, PAK5, PAK6) inhibitor |
| CAS | 1394121-05-1 |
| MW: | 406.48 D |
ab 35,00 €
