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GLPG0974
Artikelnummer: Cay28108-1
GLPG0974 is an antagonist of free fatty acid receptor 2 (FFAR2/GPR43, IC50 = 9 nM). It is selective for FFAR2 over FFAR3 at concentrations up to 30 µM and over a panel of 55 receptors, ion channels, and transporters at 10 µM. GLPG0974 inhibits acetate-induced migration of isolated human neutrophils in buffer or...
| Schlagworte: | 4-[[[(2R)-1-(benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]-butanoic acid |
| Anwendung: | FFAR2/GPR43 antagonist |
| CAS | 1391076-61-1 |
| MW: | 485 D |
ab 93,00 €
GLPG0974
Artikelnummer: TGM-T15388-10mg
Description: GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM. Target: GPR. Smiles: C[C@@]1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1. References: Pizzonero M, et al. Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic....
| Schlagworte: | GLPG-0974 |
| Anwendung: | FFAR2/GPR43 antagonist |
| CAS | 1391076-61-1 |
| MW: | 484.99 D |
ab 48,00 €
