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ML-289
Artikelnummer: Cay15195-1
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites within the receptor are being developed to preferentially target individual mGluR subtypes in order to determine...
| Schlagworte: | VU0463597, [3R-(hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone |
| Anwendung: | Negative allosteric modulator of mGlu3 |
| CAS | 1382481-79-9 |
| MW: | 349.4 D |
ab 56,00 €
ML289
Artikelnummer: TGM-T23000-100mg
Description: ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 µM), with over 15-fold selectivity compared to mGlu2 and no activity against mGlu5. Target: GluR. Smiles: COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
| Schlagworte: | VU0463597 , ML 289 |
| CAS | 1382481-79-9 |
| MW: | 349.42 D |
ab 41,00 €
