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Macozinone
Artikelnummer: TGM-T3583-100mg
Description: Macozinone (PBTZ169) inhibits decaprenylphosphoryl-beta-d-ribose 2'-oxidase (DprE1), more efficiently than BTZ043. Target: DprE1, Antibacterial. Smiles: [O-][N+](=O)c1cc(cc2c1sc(nc2=O)N1CCN(CC2CCCCC2)CC1)C(F)(F)F. References: González-Martínez NA,et al. In Vivo Activity of the Benzothiazinones PBTZ169...
| Schlagworte: | PBTZ169 |
| Anwendung: | DprE1 inhibitor |
| CAS | 1377239-83-2 |
| MW: | 456.48 D |
ab 31,00 €
PBTZ169
Artikelnummer: Cay22202-1
PBTZ169 is an antibiotic with antimycobacterial activity. It is an irreversible inhibitor of DprE1, an essential enzyme for cell wall synthesis in mycobacteria. PBTZ169 is active against M. tuberculosis in vitro (MIC = =0.19 ng/ml) without inducing cytotoxicity in Vero cells when used at concentrations up to 125 µM....
| Schlagworte: | 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
| Anwendung: | DprE1 inhibitor |
| CAS | 1377239-83-2 |
| MW: | 456.5 D |
ab 44,00 €
