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ACY-775
Artikelnummer: AG-CR1-3903-M001
Off white solid. Soluble in DMSO, methanol or ethanol. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10µ,M), Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900), Induces hyperacetylation of...
| Schlagworte: | 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1375466-18-4 |
| MW: | 330,4 D |
ab 160,00 €
ACY-775
Artikelnummer: Cay29198-1
ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 0.0075 µM). It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases alpha-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in...
| Schlagworte: | 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-5-pyrimidinecarboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1375466-18-4 |
| MW: | 330.4 D |
ab 44,00 €
