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CNX-2006
Artikelnummer: Cay30610-1
CNX-2006 is an irreversible inhibitor of mutant EGFRs. It inhibits EGFR phosphorylation in PC-9 and HCC827 cells (IC50s = 55-104 nM), which express the EGFRDel E746_A750 mutation, and NCI H1975 and PC-9/GR4 cells (IC50s = 46 and 61 nM, respectively), which express the EGFRL858R/T790M and EGFRDel E746_A750/T790M...
| Schlagworte: | N-[3-[[2-[[4-[[1-(2-fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl... |
| Anwendung: | Irreversible mutant EGFR inhibitor |
| CAS | 1375465-09-0 |
| MW: | 545.5 D |
ab 56,00 €
CNX-2006
Artikelnummer: TGM-T6008-10mg
Description: CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR. Target: EGFR. Smiles: COc1cc(NC2CN(CCF)C2)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F. References: Ohashi K, et al. 2013
| Schlagworte: | CNX2006, CNX 2006 |
| Anwendung: | Irreversible mutant EGFR inhibitor |
| CAS | 1375465-09-0 |
| MW: | 545.53 D |
ab 33,00 €
