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JNJ-46778212
Artikelnummer: TGM-T15619-100mg
Description: JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies. Target: GluR. Smiles: Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1. References: Conde-Ceide S,et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator...
| Schlagworte: | VU 0409551 |
| Anwendung: | mGluR5 positive allosteric modulator |
| CAS | 1363281-27-9 |
| MW: | 352.36 D |
ab 57,00 €
VU0409551
Artikelnummer: Cay18042-1
VU0409551 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5). It induces calcium mobilization in HEK293 cells expressing human mGluR5 (EC50 = 260 nM). It is selective for mGluR5 over mGluR1-4 and mGluR6-8 at 10 µM. VU0409551 reverses amphetamine-induced hyperlocomotion in rats...
| Schlagworte: | JNJ-46778212, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-methanone |
| Anwendung: | mGluR5 positive allosteric modulator |
| CAS | 1363281-27-9 |
| MW: | 352.4 D |
ab 44,00 €
