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ETP-46464
Artikelnummer: Cay19809-1
ETP-46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated (ATM)- and Rad3-related (ATR) with an IC50 value of 25 nM. It also inhibits mTOR and DNA-dependent protein kinase (IC50s = 0.6 and 36 nM, respectively), and is moderately active against PI3Kalpha and ATM (IC50s = 170 and 545...
| Schlagworte: | ATM Inhibitor III, ATR Inhibitor III,... |
| Anwendung: | Potent, selective ATR inhibitor |
| CAS | 1345675-02-6 |
| MW: | 470.5 D |
ab 58,00 €
ETP-46464
Artikelnummer: TGM-T2084-100mg
Description: ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM). Target: mTOR, PI3K, ATM/ATR, DNA-PK. Smiles: CC(C)(C#N)c1ccc(cc1)N1C(=O)OCc2cnc3ccc(cc3c12)-c1cnc2ccccc2c1. References: Toledo LI, et al. Nat Struct Mol Biol, 2011, 18(6), 721-727.
| CAS | 1345675-02-6 |
| MW: | 470.52 D |
ab 33,00 €
