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SR 1664
Artikelnummer: Cay11086-10
Apart from direct peroxisome proliferator-activated receptor gamma (PPARgamma) agonism, several PPARgamma ligands have recently been shown to exert anti-diabetic effects through a second, distinct biochemical function: blocking the obesity-linked phosphorylation of PPARgamma by cyclin-dependent kinase 5 (Cdk5) at...
| Schlagworte: | 4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid |
| Anwendung: | Blocks phosphorylation of PPARgamma by Cdk5 |
| CAS | 1338259-05-4 |
| MW: | 547.6 D |
ab 68,00 €
SR1664
Artikelnummer: TGM-T23389-100mg
Description: SR1664 is a potent and selective PPARgamma inhibitor with potential antidiabetic activity. SR1664 binds to PPARgamma and potently inhibits Cdk5-mediated PPARgamma phosphorylation (IC50 = 80 nM, Ki = 28.67 nM) without exhibiting PPARgamma agonist activity. Target: PPAR. Smiles:...
| Schlagworte: | SR 1664 |
| CAS | 1338259-05-4 |
| MW: | 547.6 D |
ab 46,00 €
