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PK-THPP
Artikelnummer: Cay29473-1
PK-THPP is a brain-penetrant inhibitor of the two-pore domain potassium channel K2P9.1/TASK-3 (IC50 = 0.035 µM). It is selective for K2P9.1/TASK-3 over K2P2.1/TREK1 and the voltage-gated potassium channel subtype Kv1.5 (IC50s = ~5 and >10 µM, respectively), as well as a panel of more than 100 receptors, ion...
| Schlagworte: | 1-[1-[6-([1,1'-biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone |
| Anwendung: | Brain-penetrant KCNK9 / TASK3 inhibitor |
| CAS | 1332454-07-5 |
| MW: | 468.6 D |
ab 68,00 €
PK-THPP
Artikelnummer: TGM-T24648-1mg
Description: PK-THPP is a channel blocker of TASK-3. Target: Others. Smiles: C(=O)(N1CC2=C(N=CN=C2CC1)N3CCC(C(CCC)=O)CC3)C4=CC=C(C=C4)C5=CC=CC=C5. References: Srisomboon Y, Zaidman NA, Maniak PJ, Deachapunya C, O'Grady SM. P2Y receptor regulation of K2P channels that facilitate K(+) secretion by human mammary...
| Anwendung: | Brain-penetrant KCNK9 / TASK3 inhibitor |
| CAS | 1332454-07-5 |
| MW: | 468.59 D |
ab 153,00 €
