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UNC0631
Artikelnummer: Cay11084-10
UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.Formal Name:...
| Schlagworte: | N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)... |
| Anwendung: | Potent, selective EHMT1 / EHMT2 inhibitor |
| CAS | 1320288-19-4 |
| MW: | 635.9 D |
ab 56,00 €
UNC 0631
Artikelnummer: TGM-T2354-100mg
Description: UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM). Target: Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(CC4CCCCC4)CC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C. References: Liu F, et al. J Med Chem. 2011, 54(17), 6139-6150.
| Schlagworte: | UNC0631 |
| CAS | 1320288-19-4 |
| MW: | 635.93 D |
ab 40,00 €
