Zu "129-56-6" wurden 4 Artikel gefunden!
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SP600125
Artikelnummer: Cay10010466-10
SP6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively). It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP6000125 reduces LPS-induced production of IL-1beta, IL-8, and TNF-alpha in isolated human peripheral...
| Schlagworte: | 1PMV, NSC 75890, Pyrazolanthrone, anthra[1,9-cd]pyrazol-6(2H)-one |
| Anwendung: | JNK inhibitor |
| CAS | 129-56-6 |
| MW: | 220.2 D |
ab 60,00 €
SP600125
Artikelnummer: AG-CR1-3549-M001
SP600125 is an orally active, reversible and ATP-competitive broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 (IC50 = 40nM, 40nM and 90nM, respectively). In Jurkat T cells, SP600125 suppressed the phosphorylation of c-Jun with IC50 of 5-10 µM. It has 10-fold greater selectivity against MKK4, 25-fold greater...
| Schlagworte: | Anthra[1-9-cd]pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone, Pyrazolanthrone, NSC 75890 |
| Anwendung: | Reversible, ATP-competitive JNK1/JNK2/JNK3 inhibitor |
| CAS | 129-56-6 |
| MW: | 220,2 D |
ab 22,00 €
SP600125 (Anthra(1,9-<i>cd</i>)pyrazol-6(2<i>H</i>)-one,...
Artikelnummer: LC-S-7979_100mg
Prepare initial stock solutions in DMSO (soluble at 65 mg/mL) for in vitro use, solubility in ethanol or water is low
| Schlagworte: | 1PMV, NSC 75890, Pyrazolanthrone, anthra[1,9-cd]pyrazol-6(2H)-one |
| Anwendung: | JNK inhibitor |
| CAS | 129-56-6 |
| MW: | 220,23 D |
ab 93,00 €
![Protein Kinase Inhibitor (PKI, SP600125Anthra[1,9-cd]pyrazol-6(2H)-one)](https://www.biomol.com/media/image/6d/42/b7/P9104-77A-300_200x200.jpg "Protein Kinase Inhibitor (PKI, SP600125Anthra[1,9-cd]pyrazol-6(2H)-one)")
Protein Kinase Inhibitor (PKI,...
Artikelnummer: P9104-77A.300
Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki=0.19uM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes...
| CAS | 129-56-6 |
| MW: | 220.23 |
356,00 €
