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S49076 HCl
Artikelnummer: SYN-1217-M001
Solid. Soluble in DMSO. S49076 is a novel, potent inhibitor of MET, AXL/MER and FGFR1/2/3. It can potently block cellular phosphorylation of MET, AXL and FGFRs and inhibit downstream signalling in vitro and in vivo. S49076 can inhibit the proliferation of MET- and FGFR2-dependent gastric cancer cells, block...
| Schlagworte: | S-49076 . HCl, (Z)-3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione... |
| Anwendung: | MET AXL/MER & FGFR1/2/3 inhibitor |
| CAS | 1265965-19-2 |
| MW: | 475,0 D |
ab 123,00 €
S49076 (hydrochloride)
Artikelnummer: Cay41173-1
S49076 is a multi-kinase inhibitor. It inhibits c-Met, Axl, Mer, FGFR1, FGFR2, and FGFR3 (IC50s = 1, 7, 2, 18, 17, and 15 nM, respectively). S49076 inhibits Axl- and c-Met-mediated Akt phosphorylation in MDA-MB-231 cells (IC50s = 33 and 50s = 50-200 nM). In vivo, S49076 (6.25-50 mg/kg) reduces mean tumor volume in...
| Schlagworte: | 3-[[(3Z)-2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2,4-thiazolidinedio... |
| Anwendung: | Multi-kinase inhibitor |
| CAS | 1265965-19-2 |
| MW: | 475 D |
ab 51,00 €
