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Siomycin A
Artikelnummer: Cay15378-500
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 µM), preventing the...
| Schlagworte: | NSC 285116,... |
| Anwendung: | FoxM1 expression inhibitor |
| CAS | 12656-09-6 |
| MW: | 1648.9 D |
606,00 €
Siomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741
Artikelnummer: S1013-86W.500
Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Recently, siomycin was discovered to be a potent inhibitor of the oncogenic transcription factor-forkhead box M1, FoxM1 (previously known as HFH-11B, Trident, WIN or MPP2). The reduced transcription activity was...
| CAS | 12656-09-6 |
| MW: | 1648.87 D |
653,00 €
