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Delgocitinib
Artikelnummer: TGM-T15096-100mg
Description: Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune diseases through JAK-dependent cytokines and can effectively suppress multiple...
| Schlagworte: | Corectim(Delgocitinib), JTE-052 |
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1263774-59-9 |
| MW: | 310.35 D |
ab 172,00 €
Delgocitinib
Artikelnummer: Cay38307-1
Delgocitinib is an inhibitor of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2, IC50s = 2.8, 2.6, 13, and 58 nM, respectively). It is selective for JAK1, JAK2, JAK3, and TYK2 over lymphocyte cell-specific tyrosine kinase (LCK, IC50 = 5,800 nM). Delgocitinib inhibits IL-31-induced increases in STAT3 phosphorylation...
| Schlagworte: | JTE-052, (3S,4R)-3-methyl-beta-oxo-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octane-1-propanenitrile |
| Anwendung: | JAK1 / JAK2 / JAK3 / TYK2 inhibitor |
| CAS | 1263774-59-9 |
| MW: | 310.4 D |
ab 106,00 €
