Zu "1259296-46-2" wurden 4 Artikel gefunden!
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HDAC6 Inhibitor
Artikelnummer: Cay15200-10
HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin, and heat shock protein 90, as well as other substrates. In this way, it impacts development, proliferation, invasion, and tumorigenesis. HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks...
| Schlagworte: | Histone Deacetylase 6, 1,2,3,4-tetrahydro-N-hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-6-isoquinolinecarboxamide |
| Anwendung: | Cell-permeable HDAC6 inhibitor |
| CAS | 1259296-46-2 |
| MW: | 299.3 D |
ab 85,00 €
I-BET762
Artikelnummer: SYN-3033-M100
I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762...
| Schlagworte: | GSK-525762A |
| Anwendung: | BET (bromodomain and extra terminal domain) protein BRD2 / BRD3 / BRD4 inhibitor |
| CAS | 1259296-46-2 |
| MW: | 423.9 D |
ab 123,00 €
MPI_5a
Artikelnummer: SYN-3040-M001
Solid. Soluble in DMSO. MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50...
| Schlagworte: | MPI5a, N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide |
| Anwendung: | HDAC6 inhibitor |
| CAS | 1259296-46-2 |
| MW: | 299,3 D |
ab 123,00 €
MPI_5a
Artikelnummer: TGM-T16129-100mg
Description: MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM). Target: HDAC. Smiles: C(=O)(N1CC=2C(=CC(C(NO)=O)=CC2)CC1)C=3N(C)C=CC3. References: Blackburn C, et al. Potent histone...
| Anwendung: | Cell-permeable HDAC6 inhibitor |
| CAS | 1259296-46-2 |
| MW: | 299.32 D |
ab 262,00 €
