Zu "1257044-40-8" wurden 3 Artikel gefunden!
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ABT-199
Artikelnummer: LKT-A0776.5
ABT-199 is a BH3 mimetic that inhibits Bcl-2 but does not affect Bcl-xl. ABT-199 exhibits anticancer chemotherapeutic activity, inducing Bim-mediated apoptosis in chronic lymphocytic leukemia (CLL) cells. ABT-199 also induces cell death and inhibits tumor growth in acute myelogenous leukemia (AML) models in vitro,...
| Schlagworte: | GDC-0199 |
| Anwendung: | BH3 mimetic, Bcl-2 inhibitor |
| CAS | 1257044-40-8 |
| MW: | 868.44 D |
ab 73,00 €
Venetoclax
Artikelnummer: TGM-T2119-100mg
Description: Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces autophagy and apoptosis. Target: Autophagy, BCL. Smiles:...
| Schlagworte: | GDC-0199, ABT 199, ABT-199, ABT199 |
| CAS | 1257044-40-8 |
| MW: | 868.44 D |
ab 46,00 €
ABT-199
Artikelnummer: Cay16233-10
B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death. The...
| Schlagworte: | Venetoclax, GDC 0199,... |
| Anwendung: | BCL-2 inhibitor |
| CAS | 1257044-40-8 |
| MW: | 868.4 D |
ab 80,00 €
